Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction.

The Journal of cell biology - 13 Nov 2000

Lecanda F, Warlow P M, Sheikh S, Furlan F, Steinberg T H, Civitelli R

Abstract excerpt

Connexin(Cx)43 is the major gap junction protein present in osteoblasts. We have shown that overexpression of Cx45 in osteoblasts expressing endogenous Cx43 leads to decreased cell-cell communication (Koval, M., S.T. Geist, E.M. Westphale, A.E. Kemendy, R. Civitelli, E.C. Beyer, and T.H. Steinber...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connexin 43
Share to Craniofacial Abnormalities
Share to Embryonic and Fetal Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gestational Age

Share to Neural Crest

Share to Osteoblasts

Share to Osteogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 11076975
DOI: 10.1083/jcb.151.4.931
PMCID: PMC2169447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11076975-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction.PMID 11076975Read ↗

Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation.Semantic proximity Read ↗

Characterization of hTERT-immortalized osteoblast cell lines generated from wild-type and connexin43-null mouse calvaria.Semantic proximity Read ↗

Proliferation, differentiation and apoptosis in connexin43-null osteoblasts.Semantic proximity Read ↗

ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation.Semantic proximity Read ↗

Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling.Semantic proximity Read ↗

Role of connexins and pannexins during ontogeny, regeneration, and pathologies of boneSemantic proximity Read ↗

Determining how defects in connexin43 cause skeletal disease.Semantic proximity Read ↗

Connexin43 Mutant Patient-Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential.Semantic proximity Read ↗

Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43.Semantic proximity Read ↗

Gap junction proteins exhibit early and specific expression during intramembranous bone formation in the developing chick mandible.Semantic proximity Read ↗

Skeletal abnormalities caused by a Connexin43R239Q mutation in a mouse model for autosomal recessive craniometaphyseal dysplasiaSemantic proximity Read ↗

Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.