Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis.

BMC musculoskeletal disorders - 9 Apr 2014

Lloyd Shane A, Loiselle Alayna E, Zhang Yue, Donahue Henry J

Abstract excerpt

BACKGROUND: Connexin 43 (Cx43) is the predominant gap junction protein in bone. Mice with a bone-specific deletion of Cx43 (cKO) have an osteopenic cortical phenotype. In a recent study, we demonstrated that cKO mice are resistant to bone loss induced by hindlimb suspension (HLS), an animal model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Phosphatase
Share to Connexin 43
Share to Femur

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hindlimb Suspension

Share to Osteocytes

Share to Osteolysis

Share to Porosity

Share to Tartrate-Resistant Acid Phosphatase

Source

Open in PubMed Open full text

Identifiers

PMID: 24716486
DOI: 10.1186/1471-2474-15-122
PMCID: PMC3984635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24716486-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis.PMID 24716486Read ↗

Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading.Semantic proximity Read ↗

Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading.Semantic proximity Read ↗

Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).Semantic proximity Read ↗

The G60S connexin 43 mutation activates the osteoblast lineage and results in a resorption-stimulating bone matrix and abrogation of old-age-related bone loss.Semantic proximity Read ↗

Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.Semantic proximity Read ↗

Role of connexins and pannexins during ontogeny, regeneration, and pathologies of boneSemantic proximity Read ↗

Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytesSemantic proximity Read ↗

Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation.Semantic proximity Read ↗

Proliferation, differentiation and apoptosis in connexin43-null osteoblasts.Semantic proximity Read ↗

Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction.Semantic proximity Read ↗

Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43.Semantic proximity Read ↗

The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.