Article
Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation.
Journal of cell science - 1 Feb 2017
Moorer Megan C, Hebert Carla, Tomlinson Ryan E, Iyer Shama R, Chason Max, Stains Joseph P
Abstract excerpt
In skeletal tissue, loss or mutation of the gap junction protein connexin 43 (Cx43, also known as GJA1) in cells of the osteoblast lineage leads to a profound cortical bone phenotype and defective tissue remodeling. There is mounting evidence in bone cells that the C-terminus (CT) of Cx43 is a docking platform for signaling effectors and is required for efficient downstream signaling. Here, we examined this...
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