Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2008

Grimston Susan K, Brodt Michael D, Silva Matthew J, Civitelli Roberto

Abstract excerpt

INTRODUCTION: In vitro data suggest that gap junctional intercellular communication mediated by connexin43 (Cx43) plays an important role in bone cell response to mechanical stimulation. We tested this hypothesis in vivo in a model of genetic deficiency of the Cx43 gene (Gja1). MATERIALS AND METH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to Bone Density
Share to Connexin 43

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Osteoblasts

Share to Stress, Mechanical

Share to Tomography, X-Ray Computed

Source

Open in PubMed Open full text

Identifiers

PMID: 18282131
DOI: 10.1359/jbmr.080222
PMCID: PMC2677086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18282131-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).PMID 18282131Read ↗

Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading.Semantic proximity Read ↗

Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43.Semantic proximity Read ↗

Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation.Semantic proximity Read ↗

Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading.Semantic proximity Read ↗

Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling.Semantic proximity Read ↗

Skeletal abnormalities caused by a Connexin43R239Q mutation in a mouse model for autosomal recessive craniometaphyseal dysplasiaSemantic proximity Read ↗

Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading.Semantic proximity Read ↗

The G60S connexin 43 mutation activates the osteoblast lineage and results in a resorption-stimulating bone matrix and abrogation of old-age-related bone loss.Semantic proximity Read ↗

Morphological and mechanical characterization of bone phenotypes in the Amish G610C murine model of osteogenesis imperfecta.Semantic proximity Read ↗

Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction.Semantic proximity Read ↗

Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation.Semantic proximity Read ↗

Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.