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Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone

24 May 2016

Abstract excerpt

Electron micrographs revealed the presence of gap junctions in osteoblastic cells over 40 years ago. These intercellular channels formed from connexins are present in bone forming osteoblasts, bone resorbing osteoclasts, and osteocytes (mature osteoblasts embedded in the mineralized bone matrix). More recently, genetic and pharmacologic studies revealed the role of connexins, and in particular Cx43, in the...

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PMID: 27230612
DOI: 10.1186/s12860-016-0088-6

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