Article
Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy.
Cell communication & adhesion - 1 Jan 2000
Presley Cynthia A, Lee Andrew W, Kastl Bryan, Igbinosa Irogue, Yamada Yoshiyuki, Fishman Glenn I, Gutstein David E, Cancelas Jose A
Abstract excerpt
Contact between bone marrow (BM) hematopoietic stem cells (HSC) and osteoblast/stromal (OS) cells has been shown to be crucial in the regulation of hematopoiesis. However, very little is known about the regulatory mechanisms of direct cell-to-cell communication in the hematopoietic microenvironment. Gap junction channels (connexons) are formed by polypeptides (connexins) arranged in hexamers and represent the...
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