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Article

Genetic evidence of PEBP2beta-independent activation of Runx1 in the murine embryo.

International journal of hematology - 1 Sept 2008

Yokomizo Tomomasa, Yanagida Masatoshi, Huang Gang, Osato Motomi, Honda Chikako, Ema Masatsugu, Takahashi Satoru, Yamamoto Masayuki, Ito Yoshiaki

Abstract excerpt

The Runx1/AML1 transcription factor is required for the generation of hematopoietic stem cells and is one of the most frequently targeted genes in human leukemia. Runx1-deficient mice die around embryonic day (E)12.5 due to severe hemorrhage in the central nervous system and the complete absence of definitive hematopoietic cells. Since mice lacking the heterodimeric partner of Runx1, PEBP2beta/CBFbeta, are almost...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18594778
DOI: 10.1007/s12185-008-0121-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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