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Article

Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11.

Blood - 1 Oct 2002

Kundu Mondira, Chen Amy, Anderson Stacie, Kirby Martha, Xu LiPing, Castilla Lucio H, Bodine David, Liu Pu Paul

Abstract excerpt

Core-binding factor beta (CBFbeta) and CBFalpha2 form a heterodimeric transcription factor that plays an important role in hematopoiesis. The genes encoding either CBFbeta or CBFalpha2 are involved in chromosomal rearrangements in more than 30% of cases of acute myeloid leukemia (AML), suggesting...

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Source

Identifiers

PMID: 12239155
DOI: 10.1182/blood-2002-04-1064

Genes

MYH11
CBFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12239155-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11.PMID 12239155Read ↗

Failure of Embryonic Hematopoiesis andLethal Hemorrhages in Mouse Embryos Heterozygousfor a Knocked-In Leukemia Gene CBFB–MYH11Semantic proximity Read ↗

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Core binding factor and its role in normal hematopoietic developmentSemantic proximity Read ↗

RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia developmentSemantic proximity Read ↗

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Core binding factor at the crossroads: Determining the fate of the HSCSemantic proximity Read ↗

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