Article
Mouse development with a single E2F activator.
Nature - 28 Aug 2008
Tsai Shih-Yin, Opavsky Rene, Sharma Nidhi, Wu Lizhao, Naidu Shan, Nolan Eric, Feria-Arias Enrique, Timmers Cynthia, Opavska Jana, de Bruin Alain, Chong Jean-Leon, Trikha Prashant, Fernandez Soledad A, Stromberg Paul, Rosol Thomas J, Leone Gustavo
Abstract excerpt
The E2F family is conserved from Caenorhabditis elegans to mammals, with some family members having transcription activation functions and others having repressor functions. Whereas C. elegans and Drosophila melanogaster have a single E2F activator protein and repressor protein, mammals have at least three activator and five repressor proteins. Why such genetic complexity evolved in mammals is not known. To begin...
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