Article
Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.
Development (Cambridge, England) - 1 Jul 2004
Michos Odyssé, Panman Lia, Vintersten Kristina, Beier Konstantin, Zeller Rolf, Zuniga Aimée
Abstract excerpt
Epithelial-mesenchymal feedback signaling is the key to diverse organogenetic processes such as limb bud development and branching morphogenesis in kidney and lung rudiments. This study establishes that the BMP antagonist gremlin (Grem1) is essential to initiate these epithelial-mesenchymal signaling interactions during limb and metanephric kidney organogenesis. A Grem1 null mutation in the mouse generated by...
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