Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb.

Development (Cambridge, England) - 1 Nov 2002

Liu Ying, Liu Chunqiao, Yamada Yoshihiko, Fan Chen-Ming

Abstract excerpt

Proximal-to-distal growth of the embryonic limbs requires Fgf10 in the mesenchyme to activate Fgf8 in the apical ectodermal ridge (AER), which in turn promotes mesenchymal outgrowth. We show here that the growth arrest specific gene 1 (Gas1) is required in the mesenchyme for the normal regulation of Fgf10/Fgf8. Gas1 mutant limbs have defects in the proliferation of the AER and the mesenchyme and develop with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ectoderm
Share to Extremities
Share to Fibroblast Growth Factor 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 8

Share to Fibroblast Growth Factors

Share to GPI-Linked Proteins

Share to Limb Deformities, Congenital

Share to Microinjections

Source

Identifiers

PMID: 12399319
DOI: 10.1242/dev.129.22.5289

Genes

FGF10
FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb.PMID 12399319Read ↗

Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function.Semantic proximity Read ↗

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.Semantic proximity Read ↗

Functions of FGF signalling from the apical ectodermal ridge in limb development.Semantic proximity Read ↗

Fgf10 is essential for limb and lung formationSemantic proximity Read ↗

Normal limb development in conditional mutants of Fgf4.Semantic proximity Read ↗

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning.Semantic proximity Read ↗

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.Semantic proximity Read ↗

The apical ectodermal ridge is a timer for generating distal limb progenitors.Semantic proximity Read ↗

FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.Semantic proximity Read ↗

Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.Semantic proximity Read ↗

Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.Semantic proximity Read ↗

A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.