Article
Prediction of structure and function of G protein-coupled receptors.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002
Vaidehi Nagarajan, Floriano Wely B, Trabanino Rene, Hall Spencer E, Freddolino Peter, Choi Eun Jung, Zamanakos Georgios, Goddard William A
Abstract excerpt
G protein-coupled receptors (GPCRs) mediate our sense of vision, smell, taste, and pain. They are also involved in cell recognition and communication processes, and hence have emerged as a prominent superfamily for drug targets. Unfortunately, the atomic-level structure is available for only one GPCR (bovine rhodopsin), making it difficult to use structure-based methods to design drugs and mutation experiments....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.