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Mitochondrial DNA mutations may contribute to aging via cell death caused by peptides that induce cytochrome c release.

Rejuvenation research - 1 Jun 2008

Dubec Steven J, Aurora Rajeev, Zassenhaus H Peter

Abstract excerpt

Mice wherein the wild-type mitochondrial DNA polymerase (pol gamma) is replaced by a proofreading-deficient version are born with mutation frequencies in mitochondrial DNA (mtDNA) much higher than are ever normally seen in old rodents or humans. These mice, however, are phenotypically normal at birth, raising the question regarding how the much lower frequencies observed in normal aging could possibly contribute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18593279
DOI: 10.1089/rej.2007.0617
PMCID: PMC2980764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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