Article
Selective mtDNA mutation accumulation results in beta-cell apoptosis and diabetes development.
American journal of physiology. Endocrinology and metabolism - 1 Apr 2009
Bensch Kenneth G, Mott Justin L, Chang Shin-Wen, Hansen Polly A, Moxley Michael A, Chambers Kari T, de Graaf Wieke, Zassenhaus H Peter, Corbett John A
Abstract excerpt
To test the hypothesis that somatic mitochondrial (mt)DNA mutation accumulation predisposes mice to beta-cell loss and diabetes development, transgenic mice expressing a proofreading-deficient mtDNA polymerase-gamma under the control of the rat insulin-1 promoter were generated. At 6 wk of age, mtDNA mutations reached 0.01% (1.05 mutations/10,000 bp) in islets isolated from transgenic mice. This mutational burden...
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