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Article

Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients.

PloS one - 1 Jan 2011

Lasigliè Denise, Traggiai Elisabetta, Federici Silvia, Alessio Maria, Buoncompagni Antonella, Accogli Andrea, Chiesa Sabrina, Penco Federica, Martini Alberto, Gattorno Marco

Abstract excerpt

BACKGROUND: T helper 17 cells (T(H)-17) represent a lineage of effector T cells critical in host defence and autoimmunity. In both mouse and human IL-1β has been indicated as a key cytokine for the commitment to T(H)-17 cells. Cryopyrin-associated periodic syndromes (CAPS) are a group of inflammatory diseases associated with mutations of the NLRP3 gene encoding the inflammasome component cryopyrin. In this work...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21637346
DOI: 10.1371/journal.pone.0020014
PMCID: PMC3102666

Genes

CAPS
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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