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Article

Convergent evolutionary analysis identifies significant mutations in drug resistance targets of Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Sept 2008

Hazbón Manzour Hernando, Motiwala Alifiya S, Cavatore Magali, Brimacombe Michael, Whittam Thomas S, Alland David

Abstract excerpt

Mycobacterium tuberculosis adapts to the environment by selecting for advantageous single-nucleotide polymorphisms (SNPs). We studied whether advantageous SNPs could be distinguished from neutral mutations within genes associated with drug resistance. A total of 1,003 clinical isolates of M. tuberculosis were related phylogenetically and tested for the distribution of SNPs in putative drug resistance genes. Drug...

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Identifiers

PMID: 18591265
DOI: 10.1128/AAC.00309-08
PMCID: PMC2533473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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