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Article

The GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgene.

PloS one - 1 Jan 2011

Miccio Annarita, Poletti Valentina, Tiboni Francesca, Rossi Claudia, Antonelli Antonella, Mavilio Fulvio, Ferrari Giuliana

Abstract excerpt

Gene therapy of genetic diseases requires persistent and position-independent expression of a therapeutic transgene. Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. We tested the activity of the HS2 enhancer of the GATA1 gene in protecting the expression of a β-globin minigene delivered by a lentiviral vector...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22164220
DOI: 10.1371/journal.pone.0027955
PMCID: PMC3229501

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgene.PMID 22164220Read ↗

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