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Article

Characterization of the Engrailed mutant mice as experimental models for Parkinson's disease.

Parkinsonism & related disorders - 1 Jan 2008

Sgadò Paola, Viaggi Cristina, Fantacci Chiara, Corsini Giovanni Umberto

Abstract excerpt

Engrailed genes are homeodomain-containing transcription factors necessary for the development and maintenance of mesencephalic dopaminergic neurons. Deletion in the Engrailed genes has been shown to affect the survival of mesencephalic dopaminergic neurons both during development and in the adult. Here we describe for the first time a significant reduction in striatal dopamine levels in En1+/-;En2+/- mice...

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Identifiers

PMID: 18585948
DOI: 10.1016/j.parkreldis.2008.04.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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