Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.

PloS one - 1 Jan 2017

Kouwenhoven Willemieke M, von Oerthel Lars, Smidt Marten P

Abstract excerpt

Mesodiencephalic dopaminergic (mdDA) neurons are located in the ventral midbrain. These neurons form the substantia nigra (SNc) and the ventral tegmental area (VTA). Two transcription factors that play important roles in the process of terminal differentiation and subset-specification of mdDA neurons, are paired-like homeodomain transcription factor 3 (Pitx3), and homeobox transcription factor Engrailed 1 (En1)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Cellular Reprogramming
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Green Fluorescent Proteins

Share to Homeodomain Proteins

Share to Mesencephalon

Share to Tyrosine 3-Monooxygenase

Source

Open in PubMed Open full text

Identifiers

PMID: 28800615
DOI: 10.1371/journal.pone.0182421
PMCID: PMC5553812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.PMID 28800615Read ↗

Specification of dopaminergic subsets involves interplay of En1 and Pitx3.Semantic proximity Read ↗

Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.Semantic proximity Read ↗

Genetic and epigenetic control of midbrain dopaminergic neuron development.Semantic proximity Read ↗

Transcription factors specifying dopamine phenotype are decreased in cocaine users.Semantic proximity Read ↗

EZH2 influences mdDA neuronal differentiation, maintenance and survivalSemantic proximity Read ↗

Phox2b influences the development of a caudal dopaminergic subset.Semantic proximity Read ↗

Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain.Semantic proximity Read ↗

Mesocortical Dopamine Phenotypes in Mice Lacking the Sonic Hedgehog Receptor Cdon.Semantic proximity Read ↗

Characterization of the Engrailed mutant mice as experimental models for Parkinson's disease.Semantic proximity Read ↗

Strategies to unravel molecular codes essential for the development of meso-diencephalic dopaminergic neurons.Semantic proximity Read ↗

The Shh coreceptor Cdo is required for differentiation of midbrain dopaminergic neurons.Semantic proximity Read ↗

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.