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Article

Identification of Multiple QTLs Linked to Neuropathology in the Engrailed-1 Heterozygous Mouse Model of Parkinson's Disease.

Scientific reports - 23 Aug 2016

Kurowska Zuzanna, Jewett Michael, Brattås Per Ludvik, Jimenez-Ferrer Itzia, Kenéz Xuyian, Björklund Tomas, Nordström Ulrika, Brundin Patrik, Swanberg Maria

Abstract excerpt

Motor symptoms in Parkinson's disease are attributed to degeneration of midbrain dopaminergic neurons (DNs). Heterozygosity for Engrailed-1 (En1), one of the key factors for programming and maintenance of DNs, results in a parkinsonian phenotype featuring progressive degeneration of DNs in substantia nigra pars compacta (SNpc), decreased striatal dopamine levels and swellings of nigro-striatal axons in the...

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Identifiers

PMID: 27550741
DOI: 10.1038/srep31701
PMCID: PMC4994027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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