Article
Autonomous functions for the Sec14p/spectrin-repeat region of Kalirin.
Experimental cell research - 15 Aug 2008
Schiller Martin R, Ferraro Francesco, Wang Yanping, Ma Xin-ming, McPherson Clifton E, Sobota Jacqueline A, Schiller Noraisha I, Mains Richard E, Eipper Betty A
Abstract excerpt
Kalirin is a GDP/GTP exchange factor (GEF) for Rho proteins that modulates the actin cytoskeleton in neurons. Alternative splicing generates Delta-isoforms, which encode the RhoGEF domain, but lack the N-terminal Sec14p domain and first 4 spectrin-like repeats of the full-length isoforms. Splicing has functional consequences, with Kal7 but not DeltaKal7 causing formation of dendritic spines. Cells lacking...
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