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Article

Cell organization, growth, and neural and cardiac development require αII-spectrin.

Journal of cell science - 1 Dec 2011

Stankewich Michael C, Cianci Carol D, Stabach Paul R, Ji Lan, Nath Anjali, Morrow Jon S

Abstract excerpt

Spectrin α2 (αII-spectrin) is a scaffolding protein encoded by the Spna2 gene and constitutively expressed in most tissues. Exon trapping of Spna2 in C57BL/6 mice allowed targeted disruption of αII-spectrin. Heterozygous animals displayed no phenotype by 2 years of age. Homozygous deletion of Spna2 was embryonic lethal at embryonic day 12.5 to 16.5 with retarded intrauterine growth, and craniofacial, neural tube...

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Source

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Identifiers

PMID: 22159418
DOI: 10.1242/jcs.080374
PMCID: PMC3244980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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