Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation.

PloS one - 1 Jan 2012

Tsai Yu-Chun, Riess Olaf, Soehn Anne S, Nguyen Huu Phuc

Abstract excerpt

Synphilin-1 has been identified as an interaction partner of α-synuclein, a key protein in the pathogenesis of Parkinson disease (PD). To further explore novel binding partners of synphilin-1, a yeast two hybrid screening was performed and kalirin-7 was identified as a novel interactor. We then investigated the effect of kalirin-7 on synphilin-1 aggregate formation. Coexpression of kalirin-7 and synphilin-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Guanine Nucleotide Exchange Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Histone Deacetylases

Share to Microtubules

Share to Protein Interaction Domains and Motifs

Share to Protein Transport

Share to Proteolysis

Source

Open in PubMed Open full text

Identifiers

PMID: 23284848
DOI: 10.1371/journal.pone.0051999
PMCID: PMC3527391

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation.PMID 23284848Read ↗

Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusionsSemantic proximity Read ↗

Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.Semantic proximity Read ↗

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.Semantic proximity Read ↗

Alpha synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosomeSemantic proximity Read ↗

Synphilin-1 as a modulator of aSyn assemblySemantic proximity Read ↗

Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease.Semantic proximity Read ↗

Synoretin—A New Protein Belonging to the Synuclein FamilySemantic proximity Read ↗

SUMOylation in α-Synuclein Homeostasis and PathologySemantic proximity Read ↗

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycansSemantic proximity Read ↗

The synucleins.Semantic proximity Read ↗

Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.Semantic proximity Read ↗

Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.