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Article

Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity.

Experimental cell research - 15 Jul 2005

Schiller Martin R, Blangy Anne, Huang Jianping, Mains Richard E, Eipper Betty A

Abstract excerpt

Guanine nucleotide exchange factor (GEF) domains of the Dbl family occur in a variety of proteins that include multiple protein-protein and protein-lipid interaction domains. We used an epithelial-derived cell line to investigate the mechanisms by which the two GEF domains of Kalirin, a neuronal Rho GEF, influence morphology. As expected, Kal-GEF1, an efficient GEF for Rac1 and RhoG, induced the formation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15950621
DOI: 10.1016/j.yexcr.2005.03.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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