Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae.

PLoS genetics - 27 Jun 2008

Casper Anne M, Mieczkowski Piotr A, Gawel Malgorzata, Petes Thomas D

Abstract excerpt

The ribosomal DNA (rDNA) genes of Saccharomyces cerevisiae are located in a tandem array of about 150 repeats. Using a diploid with markers flanking and within the rDNA array, we showed that low levels of DNA polymerase alpha elevate recombination between both homologues and sister chromatids, about five-fold in mitotic cells and 30-fold in meiotic cells. This stimulation is independent of Fob1p, a protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Instability
Share to DNA Polymerase I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type II

Share to Endodeoxyribonucleases

Share to Histone Deacetylases

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Share to Sirtuin 2

Share to Sirtuins

Source

Open in PubMed Open full text

Identifiers

PMID: 18584028
DOI: 10.1371/journal.pgen.1000105
PMCID: PMC2430618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae.PMID 18584028Read ↗

SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast.Semantic proximity Read ↗

A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.Semantic proximity Read ↗

Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae.Semantic proximity Read ↗

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.Semantic proximity Read ↗

Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae.Semantic proximity Read ↗

Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity.Semantic proximity Read ↗

Transcription of ribosomal genes can cause nondisjunction.Semantic proximity Read ↗

Mitotic recombination in yeast: elements controlling its incidence.Semantic proximity Read ↗

Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery.Semantic proximity Read ↗

Paf1 Counteracts transcriptional arrest to maintain rDNA stability during pol I elongation.Semantic proximity Read ↗

Sites of strong Rec12/Spo11 binding in the fission yeast genome are associated with meiotic recombination and with centromeres.Semantic proximity Read ↗

Hyper-recombination in ribosomal DNA is driven by resection-independent RAD51 loadingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.