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Article

SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast.

Cell - 14 May 2004

Kobayashi Takehiko, Horiuchi Takashi, Tongaonkar Prasad, Vu Loan, Nomura Masayasu

Abstract excerpt

It is known that mutations in gene SIR2 increase and those in FOB1 decrease recombination within rDNA repeats as assayed by marker loss or extrachromosomal rDNA circle formation. SIR2-dependent chromatin structures have been thought to inhibit access and/or function of recombination machinery in rDNA. We measured the frequency of FOB1-dependent arrest of replication forks, consequent DNA double-strand breaks, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15137938
DOI: 10.1016/s0092-8674(04)00414-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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