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Article

Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery.

Nucleic acids research - 1 Nov 2011

Houseley Jonathan, Tollervey David

Abstract excerpt

Major eukaryotic genomic elements, including the ribosomal DNA (rDNA), are composed of repeated sequences with well-defined copy numbers that must be maintained by regulated recombination. Although mechanisms that instigate rDNA recombination have been identified, none are directional and they therefore cannot explain precise repeat number control. Here, we show that yeast lacking histone chaperone Asf1 undergo...

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Identifiers

PMID: 21768125
DOI: 10.1093/nar/gkr589
PMCID: PMC3203602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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