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Article

The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development.

Journal of molecular cell biology - 1 Jul 2024

Song Xiaozhen, Hu Ruixing, Chen Yi, Xiao Man, Zhang Hong, Wu Shengnan, Lu Qing

Abstract excerpt

TRAF7 serves as a crucial intracellular adaptor and E3 ubiquitin ligase involved in signal transduction pathways, contributing to immune responses, tumor progression, and embryonic development. Somatic mutations within the coiled-coil (CC) domain and WD40 repeat domain of TRAF7 could cause brain tumors, while germline pathogenic mutations contribute to severe developmental abnormalities. However, the precise...

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Identifiers

PMID: 38178633
DOI: 10.1093/jmcb/mjad083
PMCID: PMC11216086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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