Article

Genetically regulated human <i>NODAL</i> splice variants are differentially post-transcriptionally processed and functionally distinct

2018-03-04

Abstract excerpt

NODAL is a morphogen essential for early embryonic development in vertebrates. Since much of our understanding of NODAL comes from model organisms, we aimed to directly assess post-transcriptional regulation of human NODAL with specific attention to a newly discovered human-specific NODAL splice variant. Selective depletion of the NODAL variant in human embryonic stem cells resulted in increased LIFR levels, whil...

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Literature Corpus work: 349af9db-8944-5108-b640-dd672dda728b
DOI: 10.1101/276170

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