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Article

Zebrafish organizer development and germ-layer formation require nodal-related signals.

Nature - 10 Sept 1998

Feldman B, Gates M A, Egan E S, Dougan S T, Rennebeck G, Sirotkin H I, Schier A F, Talbot W S

Abstract excerpt

The vertebrate body plan is established during gastrulation, when cells move inwards to form the mesodermal and endodermal germ layers. Signals from a region of dorsal mesoderm, which is termed the organizer, pattern the body axis by specifying the fates of neighbouring cells. The organizer is itself induced by earlier signals. Although members of the transforming growth factor-beta (TGF-beta) and Wnt families...

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PMID: 9744277
DOI: 10.1038/26013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Zebrafish organizer development and germ-layer formation require nodal-related signals.PMID 9744277Read ↗

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The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors.Semantic proximity Read ↗

Signals from the yolk cell induce mesoderm, neuroectoderm, the trunk organizer, and the notochord in zebrafish.Semantic proximity Read ↗

A novel sox gene, 226D7, acts downstream of Nodal signaling to specify endoderm precursors in zebrafish.Semantic proximity Read ↗

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