Article
Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22.
Biological psychiatry - 1 Apr 2002
Hamilton Steven P, Slager Susan L, Heiman Gary A, Deng Zemin, Haghighi Fatemeh, Klein Donald F, Hodge Susan E, Weissman Myrna M, Fyer Abby J, Knowles James A
Abstract excerpt
BACKGROUND: A well-characterized single nucleotide polymorphism (472G/A-Val/Met-SNP8) in the coding sequence of the catechol-O-methyltransferase (COMT) gene leads to a three- to fourfold difference in enzymatic activity and clinical and animal studies suggest a role in anxiety states like panic disorder. METHODS: Subjects from 70 panic disorder pedigrees, and 83 "triads", were genotyped at seven single nucleotide...
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