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Article

A theoretical study on the mechanism of a superficial mutation inhibiting the enzymatic activity of CYP1A2.

Interdisciplinary sciences, computational life sciences - 1 Mar 2014

Ma Li-Na, Du Zhen-Zhen, Lian Peng, Wei Dong-Qing

Abstract excerpt

CYP1A2, one of the major members of cytochrome P450 in human liver, participates in the metabolism of various drugs. While most harmful mutations are located near the catalytic core of CYP1A2, a recently found loss-of-function mutation, F186L, is on the surface. By far, function of this superfici...

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Identifiers

PMID: 24464701
DOI: 10.1007/s12539-014-0184-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24464701-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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