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Article

Regulation of ROS signal transduction by NADPH oxidase 4 localization.

The Journal of cell biology - 30 Jun 2008

Chen Kai, Kirber Michael T, Xiao Hui, Yang Yu, Keaney John F

Abstract excerpt

Reactive oxygen species (ROS) function as intracellular signaling molecules in a diverse range of biological processes. However, it is unclear how freely diffusible ROS dictate specific cellular responses. In this study, we demonstrate that nicotinamide adenine dinucleotide phosphate reduced oxidase 4 (Nox4), a major Nox isoform expressed in nonphagocytic cells, including vascular endothelium, is localized to the...

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Source

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Identifiers

PMID: 18573911
DOI: 10.1083/jcb.200709049
PMCID: PMC2442210

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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