Article
Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switch.
Cell death & disease - 23 Jan 2014
Yan F, Wang Y, Wu X, Peshavariya H M, Dusting G J, Zhang M, Jiang F
Abstract excerpt
Transforming growth factor-β (TGF-β) triggers apoptosis in endothelial cells, while the mechanisms underlying this action are not entirely understood. Using genetic and pharmacological tools, we demonstrated that TGF-β induced a moderate apoptotic response in human cultured endothelial cells, which was dependent upon upregulation of the Nox4 NADPH oxidase and production of reactive oxygen species (ROS). In...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.