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Article

Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae.

The Journal of clinical investigation - 1 May 2013

Weinl Christine, Riehle Heidemarie, Park Dongjeong, Stritt Christine, Beck Susanne, Huber Gesine, Wolburg Hartwig, Olson Eric N, Seeliger Mathias W, Adams Ralf H, Nordheim Alfred

Abstract excerpt

Retinal vessel homeostasis ensures normal ocular functions. Consequently, retinal hypovascularization and neovascularization, causing a lack and an excess of vessels, respectively, are hallmarks of human retinal pathology. We provide evidence that EC-specific genetic ablation of either the transcription factor SRF or its cofactors MRTF-A and MRTF-B, but not the SRF cofactors ELK1 or ELK4, cause retinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23563308
DOI: 10.1172/JCI64201
PMCID: PMC3635718

Genes

SRF
ELK1
ELK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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