Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synthetic lethality between eIF5A and Ypt1 reveals a connection between translation and the secretory pathway in yeast.

Molecular genetics and genomics : MGG - 1 Sept 2008

Frigieri Mariana C, João Luiz Marcus V S, Apponi Luciano H, Zanelli Cleslei F, Valentini Sandro R

Abstract excerpt

The putative translation initiation factor 5A (eIF5A) is a small protein, highly conserved and essential in all organisms from archaea to mammals. Although the involvement of eIF5A in translation initiation has been questioned, new evidence reestablished the connection between eIF5A and this cellular process. In order to better understand the function of elF5A, a screen for synthetic lethal gene using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carboxypeptidases
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Membranes

Share to Peptide Initiation Factors

Share to rab GTP-Binding Proteins

Share to Ribosomes

Share to Secretory Vesicles

Share to Suppression, Genetic

Source

Identifiers

PMID: 18568365
DOI: 10.1007/s00438-008-0357-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthetic lethality between eIF5A and Ypt1 reveals a connection between translation and the secretory pathway in yeast.PMID 18568365Read ↗

Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast Ypt51p and mammalian Rab5: counterparts with similar function in the early endocytic pathway.Semantic proximity Read ↗

eIF5A has a function in the elongation step of translation in yeast.Semantic proximity Read ↗

Isolation and functional characterization of a temperature-sensitive mutant of the yeast Saccharomyces cerevisiae in translation initiation factor eIF5: an eIF5-dependent cell-free translation system.Semantic proximity Read ↗

Identification of regulators for Ypt1 GTPase nucleotide cycling.Semantic proximity Read ↗

Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function.Semantic proximity Read ↗

The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway.Semantic proximity Read ↗

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.Semantic proximity Read ↗

Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling.Semantic proximity Read ↗

Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex.Semantic proximity Read ↗

eIF5A is an indispensable protein for eukaryotic cellsSemantic proximity Read ↗

Biochemical and genetic evidence for the involvement of yeast Ypt6-GTPase in protein retrieval to different Golgi compartments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.