Article
Biochemical and genetic evidence for the involvement of yeast Ypt6-GTPase in protein retrieval to different Golgi compartments.
The Journal of biological chemistry - 10 Jan 2003
Luo Zongli, Gallwitz Dieter
Abstract excerpt
Yeast Ypt6p, the homologue of the mammalian Rab6 GTPase, is not essential for cell viability. Based on previous studies with ypt6 deletion mutants, a regulatory role of the GTPase either in protein retrieval to the trans-Golgi network or in forward transport between the endoplasmic reticulum (ER) and early Golgi compartments was proposed. To assess better the primary role(s) of Ypt6p, temperature-sensitive ypt6...
Topics
- Endoplasmic Reticulum
- Glycoproteins
- Glycosylation
- Glycosyltransferases
- Golgi Apparatus
- Monomeric GTP-Binding Proteins
- Mutation
- Protein Transport
- Saccharomyces cerevisiae Proteins
- Temperature
- rab GTP-Binding Proteins
