Article
Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function.
Molecular biology of the cell - 1 Aug 2002
Cheng Hong, Sugiura Reiko, Wu Wenlian, Fujita Masaaki, Lu Yabin, Sio Susie O, Kawai Rena, Takegawa Kaoru, Shuntoh Hisato, Kuno Takayoshi
Abstract excerpt
A genetic screen for mutations synthetically lethal with fission yeast calcineurin deletion led to the identification of Ypt3, a homolog of mammalian Rab11 GTP-binding protein. A mutant with the temperature-sensitive ypt3-i5 allele showed pleiotropic phenotypes such as defects in cytokinesis, cell wall integrity, and vacuole fusion, and these were exacerbated by FK506-treatment, a specific inhibitor of...
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