Article

eIF5A is an indispensable protein for eukaryotic cells

2026-07-23

Abstract excerpt

eIF5A is an evolutionarily conserved protein found in all eukaryotes, and in Archaea and bacteria. It functions as a translation factor promoting ribosomal elongation, and it can also bind to genes in the nucleus and to mRNA. eIF5A is encoded by two paralogous genes in most eukaryotes, with one copy ( TIF51A in yeast and EIF5A1 in humans) highly expressed and essential, and the other ( TIF51B in yeast and EIF5...

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Literature Corpus work: f1bbe04a-0a74-5cf6-a50f-7acca5525711
DOI: 10.64898/2026.07.17.739231

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