Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.

doi:10.1128/mcb.11.2.872-885.1991

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Article

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.

Molecular and cellular biology - 1 Feb 1991

Dascher C, Ossig R, Gallwitz D, Schmitt H D

Abstract excerpt

In Saccharomyces cerevisiae, the GTP-binding Ypt1 protein (Ypt1p) is essential for endoplasmic reticulum-to-Golgi protein transport. By exploiting a GAL10-YPT1 fusion to regulate YPT1 expression, three multicopy suppressors, SLY2, SLY12, and SLY41, and a single-copy suppressor, SLY1-20, that allowed YPT1-independent growth were isolated. Wild-type Sly1p is hydrophilic, is essential for cell viability, and differs...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
Escherichia coli
Fungal Proteins
Genes, Fungal
Genes, Suppressor
Genes, ras
Genotype
Molecular Sequence Data
Multigene Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Proteins

R-SNARE Proteins

Receptors, Cell Surface

Restriction Mapping

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

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Identifiers

PMID: 1990290
DOI: 10.1128/mcb.11.2.872-885.1991
PMCID: PMC359739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1990290-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.PMID 1990290Read ↗

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