Identification of regulators for Ypt1 GTPase nucleotide cycling.

doi:10.1091/mbc.9.10.2819

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Article

Identification of regulators for Ypt1 GTPase nucleotide cycling.

Molecular biology of the cell - 1 Oct 1998

Jones S, Richardson C J, Litt R J, Segev N

Abstract excerpt

Small GTPases of the Ypt/Rab family are involved in the regulation of vesicular transport. Cycling between the GDP- and GTP-bound forms and the accessory proteins that regulate this cycling are thought to be crucial for Ypt/Rab function. Guanine nucleotide exchange factors (GEFs) stimulate both GDP loss and GTP uptake, and GTPase-activating proteins (GAPs) stimulate GTP hydrolysis. Little is known about GEFs and...

Topics

Base Sequence
DNA Primers
Endoplasmic Reticulum
Fungal Proteins
GTP Phosphohydrolases
GTP-Binding Proteins
GTPase-Activating Proteins
Gene Expression Regulation, Fungal
Genotype
Golgi Apparatus
Guanosine Diphosphate
Guanosine Triphosphate
Homeostasis
Kinetics

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Identifiers

PMID: 9763446
DOI: 10.1091/mbc.9.10.2819
PMCID: PMC25556

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Models, Biological

Molecular Sequence Data

Mutagenesis, Site-Directed

Point Mutation