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Article

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor.

The EMBO journal - 23 Jul 2008

Wu Jinhua, Li Wanqing, Craddock Barbara P, Foreman Kenneth W, Mulvihill Mark J, Ji Qun-sheng, Miller W Todd, Hubbard Stevan R

Abstract excerpt

The insulin-like growth factor-1 receptor (IGF1R) is a receptor tyrosine kinase (RTK) that has a critical role in mitogenic signalling during embryogenesis and an antiapoptotic role in the survival and progression of many human tumours. Here, we present the crystal structure of the tyrosine kinase domain of IGF1R (IGF1RK), in its unphosphorylated state, in complex with a novel compound,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18566589
DOI: 10.1038/emboj.2008.116
PMCID: PMC2486273

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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