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Article

Crystal structure of a conformation-selective casein kinase-1 inhibitor.

The Journal of biological chemistry - 30 Jun 2000

Mashhoon N, DeMaggio A J, Tereshko V, Bergmeier S C, Egli M, Hoekstra M F, Kuret J

Abstract excerpt

Members of the casein kinase-1 family of protein kinases play an essential role in cell regulation and disease pathogenesis. Unlike most protein kinases, they appear to function as constitutively active enzymes. As a result, selective pharmacological inhibitors can play an important role in dissection of casein kinase-1-dependent processes. To address this need, new small molecule inhibitors of casein kinase-1...

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Identifiers

PMID: 10749871
DOI: 10.1074/jbc.M001713200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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