Article
The Y39A mutation of HK022 Nun disrupts a boxB interaction but preserves termination activity.
Biochemistry - 15 Jul 2008
Burmann Björn M, Uc-Mass Augusto, Schweimer Kristian, Gottesman Max E, Rösch Paul
Abstract excerpt
Coliphage HK022 Nun protein targets phage lambda nut boxB RNA and acts as a transcriptional terminator, counteracting the phage lambda N protein, a suppressor of transcription termination. Both Nun and N protein interact directly with RNA polymerase, and Nun competes with N protein for boxB binding and prevents superinfection of Escherichia coli HK022 lysogens by lambda. Interaction of Trp18 of lambda N and A7 of...
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