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Article

Lambda nutR mutations convert HK022 Nun protein from a transcription termination factor to a suppressor of termination.

Journal of molecular biology - 20 Apr 1990

Robledo R, Gottesman M E, Weisberg R A

Abstract excerpt

The Nun protein of the lambdoid phage HK022 blocks lambda growth by terminating transcription at (or near) the lambda nut sites. An HK022 lysogen carrying a fusion of the lambda pR promoter and nutR site to a gal operon that lacks its own promoter is, therefore, Gal-. To characterize the target of Nun action, spontaneous Gal+ revertants of this strain were isolated and characterized. Two cis-acting mutations are...

Topics

Bacteriophage lambda
Base Sequence
Blotting, Northern
Genes, Viral
Mutation
Phenotype
Promoter Regions, Genetic
Repressor Proteins
Transcription Factors
Transcription, Genetic
Viral Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2139472
DOI: 10.1016/0022-2836(90)90226-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2139472-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Lambda nutR mutations convert HK022 Nun protein from a transcription termination factor to a suppressor of termination.PMID 2139472Read ↗

Escherichia coli nusG mutations that block transcription termination by coliphage HK022 Nun protein.Semantic proximity Read ↗

Overexpression of phage HK022 Nun protein is toxic for Escherichia coli.Semantic proximity Read ↗

Role of E.coli NusA in phage HK022 Nun-mediated transcription termination.Semantic proximity Read ↗

Phage HK022 Nun protein represses translation of phage lambda N (transcription termination/translation repression).Semantic proximity Read ↗

The Y39A mutation of HK022 Nun disrupts a boxB interaction but preserves termination activity.Semantic proximity Read ↗

The Escherichia coli rpoB60 mutation blocks antitermination by coliphage HK022 Q-function.Semantic proximity Read ↗

Use of a gene encoding a suppressor tRNA as a reporter of transcription: analyzing the action of the Nun protein of bacteriophage HK022.Semantic proximity Read ↗

N-mediated transcription antitermination in lambdoid phage H-19B is characterized by alternative NUT RNA structures and a reduced requirement for host factors.Semantic proximity Read ↗

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The nut site of bacteriophage lambda is made of RNA and is bound by transcription antitermination factors on the surface of RNA polymerase.Semantic proximity Read ↗

Interactions of an Arg-rich region of transcription elongation protein NusA with NUT RNA: implications for the order of assembly of the lambda N antitermination complex in vivo.Semantic proximity Read ↗

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