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Article

Coliphage HK022 Nun protein inhibits RNA polymerase translocation.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2014

Vitiello Christal L, Kireeva Maria L, Lubkowska Lucyna, Kashlev Mikhail, Gottesman Max

Abstract excerpt

The Nun protein of coliphage HK022 arrests RNA polymerase (RNAP) in vivo and in vitro at pause sites distal to phage λ N-Utilization (nut) site RNA sequences. We tested the activity of Nun on ternary elongation complexes (TECs) assembled with templates lacking the λ nut sequence. We report that Nun stabilizes both translocation states of RNAP by restricting lateral movement of TEC along the DNA register. When Nun...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24853501
DOI: 10.1073/pnas.1319740111
PMCID: PMC4060646

Genes

TEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Coliphage HK022 Nun protein inhibits RNA polymerase translocation.PMID 24853501Read ↗

Phage HK022 Nun protein represses translation of phage lambda N (transcription termination/translation repression).Semantic proximity Read ↗

Role of E.coli NusA in phage HK022 Nun-mediated transcription termination.Semantic proximity Read ↗

Overexpression of phage HK022 Nun protein is toxic for Escherichia coli.Semantic proximity Read ↗

Lambda nutR mutations convert HK022 Nun protein from a transcription termination factor to a suppressor of termination.Semantic proximity Read ↗

Use of a gene encoding a suppressor tRNA as a reporter of transcription: analyzing the action of the Nun protein of bacteriophage HK022.Semantic proximity Read ↗

The Y39A mutation of HK022 Nun disrupts a boxB interaction but preserves termination activity.Semantic proximity Read ↗

Escherichia coli nusG mutations that block transcription termination by coliphage HK022 Nun protein.Semantic proximity Read ↗

Regulation of promoter-proximal transcription elongation: enhanced DNA scrunching drives λQ antiterminator-dependent escape from a σ70-dependent pause.Semantic proximity Read ↗

NusA interaction with the α subunit of E. coli RNA polymerase is via the UP element site and releases autoinhibition.Semantic proximity Read ↗

The nut site of bacteriophage lambda is made of RNA and is bound by transcription antitermination factors on the surface of RNA polymerase.Semantic proximity Read ↗

The antiterminator RNA of phage HK022.Semantic proximity Read ↗

A protein-RNA interaction network facilitates the template-independent cooperative assembly on RNA polymerase of a stable antitermination complex containing the lambda N protein.Semantic proximity Read ↗

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