Article
Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex.
Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2002
Jones David E J, Palmer Jeremy M, Bennett Kate, Robe Amanda J, Yeaman Stephen J, Robertson Helen, Bassendine Margaret F, Burt Alastair D, Kirby John A
Abstract excerpt
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by autoreactive T- and B-cell responses to the highly conserved enzyme pyruvate dehydrogenase complex (PDC). In this study we have examined the breakdown of T-cell tolerance to self-PDC using a mouse model. Female SJL/J mice were sensitized intraperitoneally with foreign-PDC (bovine) and/or self-PDC (murine) in complete Freund's...
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