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Article

Primary biliary cirrhosis: an orchestrated immune response against epithelial cells.

Immunological reviews - 1 Apr 2000

Gershwin M E, Ansari A A, Mackay I R, Nakanuma Y, Nishio A, Rowley M J, Coppel R L

Abstract excerpt

Primary biliary cirrhosis (PBC) is an organ-specific autoimmune disease that predominantly affects women and is characterized by chronic progressive destruction of small intrahepatic bile ducts with portal inflammation and ultimately fibrosis. The serologic hallmark of PBC is the presence of antibodies to mitochondria, especially to the E2 component of the pyruvate dehydrogenase complex. The mechanisms by which...

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Share to Bile Ducts
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10807518
DOI: 10.1034/j.1600-0528.2002.017402.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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