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Article

A genome-wide exploration suggests an oligogenic model of inheritance for the TAFI activity and its antigen levels.

Human genetics - 1 Aug 2008

Sabater-Lleal Maria, Buil Alfonso, Souto Juan Carlos, Alamsy Laura, Borrell Montserrat, Lathrop Mark, Blangero John, Fontcuberta Jordi, Soria José Manuel

Abstract excerpt

Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) is a protein that potently attenuates fibrinolysis. A considerable proportion of its variability levels is genetically determined. It has been associated with arterial and venous thrombosis. We conducted a Genome Wide Scan for genes affecting variation in plasma TAFI levels in 398 subjects from 21 extended Spanish families. The data were analyzed by a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18563448
DOI: 10.1007/s00439-008-0527-3
PMCID: PMC2592198

Genes

CPB2

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