C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies.

doi:10.1182/blood-2010-01-263038

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C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies.

Blood - 10 Jun 2010

Buil Alfonso, Trégouët David-Alexandre, Souto Juan Carlos, Saut Noémie, Germain Marine, Rotival Maxime, Tiret Laurence, Cambien Françcois, Lathrop Mark, Zeller Tanja, Alessi Marie-Christine, Rodriguez de Cordoba Santiago, Münzel Thomas, Wild Philipp, Fontcuberta Jordi, Gagnon France, Emmerich Joseph, Almasy Laura, Blankenberg Stefan, Soria José-Manuel, Morange Pierre-Emmanuel

Abstract excerpt

Through its binding with protein S (PS), a key element of the coagulation/fibrinolysis cascade, the C4b-binding protein (C4BP) has been hypothesized to be involved in the susceptibility to venous thrombosis (VT). To identify genetic factors that may influence the plasma levels of the 3 C4BP existing isoforms, alpha(7)beta(1), alpha(6)beta(1), and alpha(7)beta(0), we conducted a genome-wide association study by...

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PMID: 20212171
DOI: 10.1182/blood-2010-01-263038
PMCID: PMC2890187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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